Multiple Dose Activated Charcoal In The Management Of Drug Overdose: A Pharmacokinetic Based Study

Document Type : Research articles

Authors

1 Clinical pharmacy Department, College of Pharmaceutical sciences and Drug Manufacturing, Misr University for Science and Technology

2 Clinical Pharmacy Department, Faculty of Pharmacy, Helwan University

3 Department of Forensic Medicine & Toxicology, Faculty of Medicine, Ain Shams University

4 Poison control center, Ain-Shams University

5 Department of Biochemistry, Poison control center, Ain-Shams University

Abstract

Managing acute poisoning remains an important part of accident and emergency care. Several gastric decontamination procedures have been widely used and their role has recently been reviewed and position statements developed by working groups of the American Academy of Clinical Toxicology and the European Association of Poisons Centers and Clinical Toxicologists. Nowadays, activated charcoal is a useful adsorbent for gastric decontamination. Enhancement of elimination may involve multiple dosing of activated charcoal, hemodialysis, or charcoal hemoperfusion.

Nowadays, activated charcoal is a useful adsorbent for gastric decontamination. Enhancement of elimination may involve multiple dosing of activated charcoal, diuresis hemodialysis, or charcoal hemoperfusion. In addition, gastrointestinal decontamination has been practiced for hundreds of years; however, only in the past few years have data emerged that only some patients demonstrate a clinical benefit. Because most potentially toxic ingestions involve agents that are not toxic in the quantity consumed, the exact circumstances in which decontamination is beneficial and which methods are most beneficial in those circumstances remain important topics of research.



This study aims to determine the rational use of Multiple Dose Activated Charcoal in poisoning centers, and to study the efficacy of Multiple Dose Activated Charcoal as enhanced elimination modality in different acute toxicities depending on Pharmacokinetics principles. Results show that, Theophylline, paracetamol, carbamazepine and salicylates are all adsorbable by activated charcoal, activated charcoal barely affects the elimination of valproic acid

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