Recently Identified MicroRNAs as Potential Diagnostic and Prognostic Biomarkers in Acute coronary syndrome

Document Type : Review Articles.

Authors

1 Department of Biochemistry, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th October City, Giza, Egypt.

2 College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt

Abstract

Background: Cardiovascular diseases (CVDs) remain the most prevalent cause of mortality globally. Acute coronary syndrome (ACS) is a category of CVDS with a high fatality rate. Thus, early diagnosis and effective management of ACS are crucial to improve patient outcomes. Biomarkers, which are measurable biological indicators, have emerged as essential tools for the diagnosis, prognosis, and risk stratification of ACS. Recently, small non-coding RNAs (miRs) have been found to affect messenger RNA (mRNA) stability by either suppressing their translation or promoting their degradation through complementary base pairing, thereby acting as negative regulators of protein translation. Moreover, miRs play a key role in regulating various signaling pathways and cellular functions, including intercellular communication. Aim and concept of review: Since miRs expression has been identified in the blood of patients with various cardiovascular conditions, they are regarded as promising noninvasive biomarkers. This study provides an overview of the existing literature on the role of miRs in ACS. Conclusion: The findings suggest that miRs could serve as potential diagnostic and prognostic biomarkers in ACS, and hence, miR regulation may offer new perspectives for therapeutic interventions in ACS.

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